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After the first 3 months of therapy, patients on the drug had a higher rate of hospitalization than patients taking a placebo.
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ALTHOUGH CROUP is usually a selflimited illness, it causes a significant health care burden through frequent emergency department visits and hospitalizations, as well as physician office visits.1 By the early 1990s, evidence clearly supported the use of glucocorticoids for children with croup who required hospitalization.2-5 This development created interest in examining the effectiveness of glucocorticoid treatFrom the Departments of Pediatrics Drs Klassen, Osmond, and Watters, Ms Moher, and Mr Sutcliffe ; , and Epidemiology and Community Medicine Dr Klassen and Mr Moher ; , University of Ottawa, Ottawa, Ontario; the Department of Child Health, University of Manitoba, Winnipeg Drs Craig and Pasterkamp and the Department of Pediatrics, Johns Hopkins University, Baltimore, Md Dr Rowe ; . Reprints: Terry P. Klassen, MD, Research Institute, Children's Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, Ontario, Canada K1H 8L1 e-mail: terry.klassen sympatico.
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39. Hall A. G proteins and small GTPases: distant relatives keep in touch. Science. 1998; 280: 2074 McGwin GJ Jr, McNeal S, Owlsey C, Girkin C, Epstein D, Lee PP. Statins and other cholesterol-lowering medications and the presence of glaucoma. Arch Ophthalmol. 2004; 122: 822 Garcia JGN, Davi HW, Patterson CE. Regulation of endothelial cell gap formation and barrier dysfunction: role of myosin light chain phosphorylation. J Cell Physiol. 1995; 163: 510 Orford K, Orford CC, Byer SW. Exogenous expression of betacatenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest. J Cell Biol. 1999; 146: 855 Johnson DH, Tschumper RC. The effect of organ culture on human trabecular meshwork. Exp Eye Res. 1989; 49: 113127. Vittitow JL, Garg R, Rowlette LL, Epstein DL, O'Brien ET, Borras T. Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures. Mol Vis. 2002; 8: 32 Bill A, Lutjen-Drecoll E, Svedbergh B. Effects of intracameral Na2EDTA and EGTA on aqueous outflow routes in the monkey eye. Invest Ophthalmol Vis Sci. 1980; 19: 492504. Chrzanowski-Wodnicka M, Burridge K. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol. 1996; 133: 14031415. Hall A. Rho GTPases and actin cytoskeleton. Science. 1998; 279: 509 Kaubuchi K, Kuroda S, Amano M. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu Rev Biochem. 1999; 68: 459 Wettschureck N, Offermanns S. Rho Rho-kinase mediated signaling in physiology and pathophysiology. J Mol Med. 2002; 80: 629 Somylo AP, Somylo A. Signal transduction by G-proteins, Rhokinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol. 2000; 522: 177185. Kamm KE, Stull JT. The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Ann Rev Pharmacol Toxicol. 1985; 25: 593 Laufs U, Liao J K. Targeting Rho in cardiovascular disease. Circ Res. 2000; 87: 526 Laufs U, Kilter H, Konkol C, Wassmann S, Bohm M, Nickenig G. Impact of HMG CoA reductase inhibition on small GTPases in the heart. Cardiovasc Res. 2002; 53: 911920. Li X, Liu L, Tupper JC, et al. Inhibition of protein geranylgeranylation and RhoA RhoA kinase pathway induces apoptosis in human endothelial cells. J Biol Chem. 2002; 277: 15309 Goeckeler ZM, Wysolmerski RB. Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation. J Cell Biol. 1995; 130: 613 Thieme H, Nuskovski M, Nass JU, Pleyer U, Strauss O, Wiederholt M. Mediation of calcium-independent contraction in trabecular meshwork through protein kinase C and rho-A. Invest Ophthalmol Vis Sci. 2000; 41: 4240 Corsini A. The safety of HMG-CoA reductase inhibitors in special populations at high cardiovascular risk. Cardiovasc Drugs Ther. 2003; 17: 265285. Swiercz JM, Kuner R, Behrens J, Offermanns S. Plexin-B1 directly interacts with PDZ-RhoGEF LARG to regulate RhoA and growth cone morphology. Neuron. 2002; 35: 51 Cheng Q, Sasaki Y, Shoji M, et al. Cdk5 p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells. Mol Cell Neurosci. 2003; 24: 632.
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Key note speaker , Speaker , Poster TREATMENT OF SKIN CANCER IN CHILDREN D. Zikirjakhodjaev, Z. Huseinov, D. Nishonov, R. Uldoshev The Pediatric Cancer Service, as an independent division of the Republican Clinical Cancer Center of the Ministry of Public Health of the Republic of Tajikistan Dushanbe ; , was organized in 1980. There are also a children's department in the regional cancer center of Khudzand and wards with beds for children in the cancer prophylactic centers of Kulab, Kurgan-Tube and Khorog. In our department we treat children with tumors in various localizations, except tumors of the blood and nervous systems. The department is designed for thirty beds. Since children come to our department for treatment from all regions of Tajikistan, we treat various types of tumors. It is necessary to note that during the last six years since 1999 ; , the cancer morbidity rate in children has increased almost by 20%. We have mostly treated lymphomas 56% ; and more often nonHodgkin's lymphoma 30% ; . The second and third most common children's cancers treated in our department were retinoblastoma and nephroblastoma 7-8% ; . There are frequently bone tumors, tumors of soft tissue and skin. Less often there are other malignant tumors, such as teratoblastomas of various localizations. On average, in one year there may be about 250 patients in our department who need special medical attention. The ratio of boys to girls is 1.6: 1, on average. Combined and complex treatments of different types of malignant tumors in children, including surgical treatment, chemotherapy, and cryodestruction of tumors are carried out in our department. Taking into account the fact that there is no department specializing in incurable children in our center, nor in the Republic as a whole, we must carry out palliative and symptomatic treatment of the patients in our department. Polychemotherapy is first among the methods of treatment that we use, depending on the features of the malignant tumors' structure mainly lymphomas ; , especially since we have plenty of primary inoperable children. Our department has treated 17 children with locally spread skin cancer ranging in age from 4 to 16 years, including 11 boys and six girls. In the complex treatment of these patients, we.
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Action: metoprolol lopressor ; is a selective beta1 blocking agent use: in the pre-hospital setting, metoprolol is indicated for the treatment of hemodynamically stable patient with a definite or suspected acute myocardial infarction.
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37. Merlo J, Liedholm H, Lindblad U, Bjorck-Linne A, Falt J, Lindberg G, et al. Prescriptions with potential drug interactions dispensed at Swedish pharmacies in January 1999: cross sectional study. Bmj 2001; 323 7310 ; : 427-8. 38. Hakansson A, Andersson H, Cars H, Melander A. Prescribing, prescription costs and adherence to formulary committee recommendations: long-term differences between physicians in public and private care. Eur J Clin Pharmacol 2001; 57 1 ; : 65-70.
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