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NaHCO3 when necessary ; were stored at 80C, and working solutions were prepared daily by dilution in aCSF at the stated concentrations and applied by reverse dialysis uncorrected for drug recovery ; . Control rats and mice were perfused with aCSF. The bars in the figures show the period of drug application corrected for the void volume of the system ; . Single-unit recordings. We examined the responses of VTA DA neurons to the systemic administration of drugs. Rats were anesthetized chloral hydrate, 400 mg kg, i.p. ; and positioned in a David Kopf stereotaxic frame. Thereafter, chloral hydrate was continuously administered intraperitoneally at a dose of 50 70 mg kg h using a perfusion pump Fa et al., 2003 ; . Body temperature was maintained at 37C with a heating pad. DA neurons were recorded extracellularly with glass micropipettes pulled from 2 mm capillary glass World Precision Instruments, Sarasota, FL ; on a Narishige Tokyo, Japan ; PE-2 pipette puller. Microelectrodes were filled with 2 M NaCl. Typically, impedance was 4 10 M Single-unit extracellular recordings were amplified with a Neurodata IR283 Cygnus Technology, Delaware Water Gap, PA ; , postamplified and filtered with a Cibertec Madrid, Spain ; amplifier and computed on-line using a DAT 1401 plus interface system Spike2 software Cambridge Electronic Design, Cambridge, UK ; . Descents in the VTA were performed at anteroposterior AP ; 5.0 to 5.6, lateral L ; 0.5 to 1, and dorsoventral DV ; 7.5 to 9.0 to record DA neurons in both the parabraquial and paranigral subdivisions. The identification of DA neurons and burst-firing analysis was performed according to the criteria of Grace and Bunney 1984 ; , as used previously Celada et al., 1999 ; . Briefly, neurons were considered dopaminergic if they possessed the following characteristics: 1 ; action poten, for instance, kenalog.
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