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This project is funded by populations and health issues directorate at health canada, for example, buy carbimazole. Preamble . Introduction . 1.1. Organization of committee and evidence review . 1.2. Contents of these guidelines . 1.3. Changes since the initial publication of these guidelines in 2001 . Definition . 2.1. Atrial fibrillation . 2.2. Related arrhythmias . Classification . Epidemiology and prognosis . 4.1. Prevalence . 4.2. Incidence . 4.3. Prognosis . Pathophysiological mechanisms 5.1. Atrial factors 5.1.1. Atrial pathology as a cause of atrial fibrillation . 5.1.1.1. Pathological changes caused by atrial fibrillation . 5.1.2. Mechanisms of atrial fibrillation . 5.1.2.1. Automatic focus theory . 5.1.2.2. Multiple-wavelet hypothesis . 5.1.3. Atrial electrical remodeling . 5.1.4. Counteracting atrial electrical remodeling 5.1.5. Other factors contributing to atrial fibrillation . 5.2. Atrioventricular conduction . 5.2.1. General aspects . 5.2.2. Atrioventricular conduction in patients with preexcitation syndromes 5.3. Myocardial and hemodynamic consequences of atrial fibrillation 5.4. Thromboembolism . 5.4.1. Pathophysiology of thrombus formation 5.4.2. Clinical implications . Causes, associated conditions, clinical manifestations, and quality of life . 6.1. Causes and associated conditions . 6.1.1. Reversible causes of atrial fibrillation . 6.1.2. Atrial fibrillation without associated heart disease . 6.1.3. Medical conditions associated with atrial fibrillation . 6.1.4. Atrial fibrillation with associated heart disease . 6.1.5. Familial Genetic ; atrial fibrillation 6.1.6. Autonomic influences in atrial fibrillation . 6.2. Clinical manifestations . 6.3. Quality of life . Clinical evaluation . 7.1. Basic evaluation of the patient with atrial fibrillation . 7.1.1. Clinical history and physical examination . 7.1.2. Investigations . 7.2. Additional investigation of selected patients with atrial fibrillation . 654 655. 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