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Increase marketing capacity through strategic partnerships. Gentium has entered into a strategic license agreement with Sigma-Tau Pharmaceuticals, Inc. to market Defibrotide to treat VOD in North America, Central America, and South America upon regulatory approval and has granted Sigma-Tau Pharmaceuticals a right of first refusal to market Defibrotide to prevent VOD, to mobilize and increase the number of stem cells available for transplant, and in non-intravenous forms. Gentium could pursue similar agreements with Sigma-Tau Pharmaceuticals and other strategic partners to market Defibrotide in other jurisdictions and to market other product candidates. The Company's state-of-the-art manufacturing facility at headquarters in Como, Italy is currently used for active pharmaceutical ingredients and Defibrotide. This facility underwent a $10 million upgrade in 2004 and is FDA GMP-compliant. Gentium owns the land, buildings, laboratories, and equipment. The Company holds 30 U.S. and EU patents with 70 applications pending. Defibrotide's Orphan Drug designation in the U.S. and Europe provides additional market exclusivity for the treatment of VOD. Gentium continues to build on its core patents to provide additional protection. With proforma cash of approximately $32 million as of March 31, 2006, Gentium has approximately one to two years of cash remaining.

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Eventy five years ago, Dr. Erik von Willebrand first described an inherited bleeding disorder that manifests as excessive bleeding from mucous membranes and into the skin in a large family in the Aaland Islands in Scandinavia. The index case in his studies, a 14 year old girl, subsequently died as a result of excessive bleeding associated with menstruation. The condition described by Dr. von Willebrand now bears his name and is recognized as the most common inherited bleeding disorder known in humans. Introduction to von Willebrand Disease Over the past decade, with the increasing realization that von Willebrand Disease vWD ; was not a rare condition, but in fact a very common, usually mild, bleeding disorder, interest in the diagnosis and improved clinical management of the condition has increased significantly. Furthermore, recognition that the major health problem associated with vWD is heavy bleeding associated with menstruation, has also begun to affect the practice of gynecologists and family physicians who see large numbers of women with this concern. The primary abnormality in vWD, for example, yugo amaryl.
we have made great advances over the past decade in the effective treatment of chronic hepatitis c, one of the most common blood borne infections in the world,  said robert spiegel chief medical officer and senior vice president of medical affairs, schering-plough research institute and aricept.

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Dean Crain is from Vancouver, where he worked as a stockbroker until he was diagnosed with HD in July 2000 at the age of 46. Dean explained that he considers himself to be a very lucky person. He grew up in the projects of Vancouver and yet was able to find a career that he loved and did well at. He met and married his "beautiful and intelligent" wife Linda, and they had two children. Dean talked about making a To Do list after his diagnosis. He listed all the things that he wanted to be sure that he did while he was still able. One of the most important things on his list is to spend as much time as possible with his children. Other items on his list are travelling, which he is doing, and trying some new things like fishing. With a great deal of humour Dean said that he knew exercise is important for people with HD, but described how he would rather "spit straight up than go to the gym." He decided that he would go back to running, which he had always loved. 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The consultation begins before the consultation begins. Have you ever been a patient or been around one of your own loved one's medical encounters? These experiences are among your best teachers. Was it good? "Why was I referred, what will they find, will I appear stupid, will the wait for the appoint. Pediatrics A, Soroka University Medical Center, 2Microbiology, 3Pathology, 4Nephrology, Ben Gurion University, 5Nephrology, Soroka University Medical Center, Beer Sheva, Israel Introduction: Premature cardiovascular disease is the most common cause of morbidity and mortality in diabetes mellitus DM ; . Hypertension and albuminuria are major risk factors for the development of vascular complications. A major mediator of diabetic complications is the renin-angiotensin system. The angiotensin-converting enzymes ACE and ACE2 ; regulate angiotensin II mediated vasoconstriction as well as fibrosis in heart tissue. The relative contribution of hypertension Vs DM in diabetic heart disease is not well defined. The study purpose was to characterize the myocardium changes in an animal model of hypertension and DM, with high attention to the local RAS. Methods: The male Sabra rat model SBH y ; of salt induced hypertension was used. The experimental groups included: control non-diabetic C ; , diabetic D ; induced by streptozotocin ; , and D or C rats fed with 8% NaCl-containing chow DSalt or CSalt ; . Experimentation was started at age 4 weeks and animals were sacrificed 6 weeks afterwards. Results: Systolic blood pressure BP ; prior to sacrifice was 1393 mmHg in C, but decreased in D 1284 mmHg, p 0.001 ; . BP at sacrifice was raised in CSalt and DSalt 1753 and 1815 mmHg respectively, p 0.001 ; . Differences in BP began at the third week of the experiment. Heart weight to body weight ratio HW BW ; was increased in CSalt and DSalt but also in normotensive D animals. Beta myosin heavy chain, atrial natriuretic peptide ANP ; and cardiac alpha actin expression were significantly increased in D and DSalt compared to C and CSalt. A similar pattern was seen for type III collagen and TGF-beta mRNA levels. Myocardial ACE mRNA levels were increase in D and DSalt compared to C and CSalt. In addition, ACE2 mRNA levels were decreased in both D and DSalt groups compared to CSalt. Conclusion: Early cardiac remodeling is evident in normotensive DM rats and elevated BP contributes no additional effect in this model. These changes are associated with an increase in ACE and a decrease in ACE2 gene expression, suggesting an increase in free angiotensin II tissue levels in DM, for example, aventis amaryl!
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